Lake Superior State University
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Tyler graduated from Saline High School in Saline, Michigan. He has been an active leader at Anchorhouse Christian Fellowship. He completed his senior research on the use of microreactors to produce pharmaceutical precursors. He was the recipient of a GRO Fellowship for Undergraduates sponsored by the EPA. Tyler completed a summer working in Cinncinati for the EPA's National Risk Management Research Laboratory, and spent a summer in San Francisco with the American Chemical Society's Nuclear Summer School. Tyler will be pursuing his PhD at Washington State University in the Fall.

Tyler O'Dell
2010 Outstanding Graduate
Chemistry

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Asymmetric Synthesis Using Chiral Auxiliaries and Titanium Enolates

Michael Overbeek

Chiral auxiliary-mediated asymmetric aldol additions are an important method for asymmetric carbon-carbon bond formation. Dr. Daveid A. Evans from Harvard University has developed the use of a boron enolate to allow for specific stereochemistry, often called an ďEvanís Aldol Reactioní. The use of a titanium enolate, instead of a borony enolate, has been documented to create the opposite stereocenters when utilizing the Evanís Aldol methodology. This project describes an attempt to form an anti-Evans product with the addition of phenylacetaldehyde to R-(-)-4-Benzyl-3propionyl-2oxazolidinone. The use of an aldehyde substrate when utilizing a chiral titanium enolate has not been well documented in the literature.

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